Related Experiment Video

Updated: Nov 1, 2025

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears
10:27

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

10.8K

Comparison of inner ear deficits in Meniere's variants and their significance

Yu-Jr Jeng1, Yi-Ho Young1

  • 1Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.

Acta Oto-Laryngologica
|June 22, 2021
PubMed
Abstract

Insights

Inner ear test results in Meniere's disease patients with falls align with those after sac surgery, suggesting a shared mechanism. Patients without falls showed distinct patterns in vestibular-evoked myogenic potential and caloric tests.

Area of Science:

  • Otolaryngology
  • Neuroscience
  • Vestibular System Research

Background:

  • Meniere's disease (MD) exhibits a declining order of inner ear test abnormalities.
  • This pattern correlates with the prevalence of endolymphatic hydrops in MD temporal bone donors.

Purpose of the Study:

  • To investigate and compare inner ear deficits in Meniere's disease patients experiencing falls, those without falls, and individuals post-sac operation.

Main Methods:

  • Enrolled 60 Meniere's disease patients: 20 with falls (Group A), 20 without falls (Group B), and 20 post-sac operation (Group C).
  • Administered a comprehensive inner ear test battery to all participants.

Main Results:

  • Group A (falls) showed abnormality rates: audiometry (92%), cVEMP (71%), caloric (42%), oVEMP (38%).
  • Group B (no falls) presented a different sequence: audiometry, cVEMP, oVEMP, caloric.
  • Group C (post-sac operation) mirrored Group A's sequence, suggesting a shared underlying mechanism.

Conclusions:

  • The declining sequence of inner ear deficits differs between Meniere's disease patients with and without falls.
  • Similarities in deficit patterns between fall-prone MD patients and those post-sac operation suggest shared pathophysiological mechanisms.
Keywords:
Cervical vestibular-evoked myogenic potential (cVEMP)Tumarkin fallsdrop attackocular vestibular-evoked myogenic potential (oVEMP)sac operation

More Related Videos

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease04:11

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

1.9K
Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

1.2K

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
5.3K
The Vestibular System01:29

The Vestibular System

The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
41.7K
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.7K
Anatomy of the Ear01:16

Anatomy of the Ear

Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
9.5K