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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Keloidal pathophysiology: Current notions.

Chenyu Huang1, Rei Ogawa2

  • 1Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

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Summary
This summary is machine-generated.

Keloids are aggressive scars that invade healthy skin and often recur after treatment. Understanding their mechanobiology is key to developing new therapies for keloid scar management.

Keywords:
Keloidendothelial cellsextracellular matrixinflammationmechanobiologymechanosignalling pathway

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Area of Science:

  • Dermatology
  • Pathophysiology
  • Biomedical Engineering

Background:

  • Keloids are pathological scars characterized by relentless invasion into surrounding healthy skin.
  • Recurrence is common after standard monotherapies and surgical interventions.
  • Cellular players include lymphocytes, macrophages, mast cells, and endothelial cells, influenced by various systemic and local factors.

Purpose of the Study:

  • To provide a comprehensive review of keloid pathophysiology.
  • To elucidate the multifactorial nature of keloidogenesis.
  • To highlight the role of mechanobiology in keloid formation and progression.

Main Methods:

  • Systematic literature review of keloid pathophysiology.
  • Searches conducted in PubMed, Embase, and Web of Science databases.
  • Evaluation of evidence levels from retrieved articles.

Main Results:

  • Detailed description of keloid morphology, clinical signs, and histopathological changes.
  • Exploration of proposed theories including endocrinological, nutritional, vascular, and autoimmunological factors.
  • Analysis of local mechanical forces and mechanosignalling pathways influencing keloid cell activity, invasion direction, and prone body sites.

Conclusions:

  • Enhanced understanding of keloid mechanobiology is crucial for advancing diagnostic and therapeutic strategies.
  • New approaches may prevent, reduce, or reverse the progression of these pathological scars.
  • Targeting mechanobiology offers potential for improved clinical management of keloids.