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Related Experiment Video

Updated: Nov 1, 2025

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

Spleen angiosarcoma: a world review.

Brian Lee Juin Hsien¹, Vishal Girishchandra Shelat²

¹Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Expert Review of Gastroenterology & Hepatology

|June 23, 2021

Summary

This summary is machine-generated.

Spleen angiosarcoma (SA) is a rare cancer. A comprehensive review highlights nonspecific presentations, recommending a triple assessment for accurate diagnosis and splenectomy as the primary treatment for this vascular endothelial neoplasm.

Keywords:

Angiosarcoma anemia asplenia hypersplenism rupture spleen splenomegaly thrombocytopenia

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Last Updated: Nov 1, 2025

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Area of Science:

Oncology
Surgical Pathology
Vascular Neoplasms

Background:

Spleen angiosarcoma (SA) is an exceptionally rare malignancy originating from splenic vascular endothelium.
Limited reported cases hinder understanding of SA's presentation, diagnosis, and management.

Purpose of the Study:

To conduct a comprehensive literature review of spleen angiosarcoma.
To analyze patient demographics, risk factors, clinical presentations, diagnostic methods, therapies, and outcomes.

Main Methods:

Systematic literature search of PubMed and Embase databases conducted on February 27, 2021.
Inclusion of 122 articles detailing 205 patient cases.
Analysis focused on identifying potential risk factors, diagnostic modalities, and therapeutic principles.

Main Results:

Clinical presentations and investigation results for SA are frequently nonspecific.
A combination of clinical examination, imaging, and pathology is crucial for accurate diagnosis.
Splenectomy is identified as the primary management strategy.

Conclusions:

A triple assessment approach (clinical, imaging, pathology) is recommended for high-accuracy SA diagnosis.
Splenectomy should be the cornerstone of SA treatment.
Chemotherapy and radiotherapy serve as adjuncts, particularly for metastatic disease.