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Updated: Nov 1, 2025
09:57
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
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Disulfide-containing Macromolecules for Therapeutic Delivery.
Ziwen Jiang1, S Thayumanavan1,2,3
1Department of Chemistry, University of Massachusetts Amherst, Massachusetts 01003, United States.
Israel Journal of Chemistry
|June 25, 2021
Summary
Synthetic polymers with disulfide bonds are key for drug delivery. This overview explores their design and the role of disulfide bonds in advanced therapeutic systems.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Drug Delivery Systems
Background:
- Macromolecules serve as essential platforms for therapeutic delivery.
- Synthetic polymers offer tunable properties for advanced applications.
- Disulfide bonds are crucial functional groups in polymer design.
Purpose of the Study:
- To provide an overview of synthetic polymer design principles for therapeutic delivery.
- To highlight the role of disulfide bonds in polymer architecture (backbone or side chains).
- To identify current knowledge gaps and future research directions regarding disulfide bonds in drug delivery.
Main Methods:
- Review of design principles for synthetic polymers incorporating disulfide bonds.
- Analysis of the functional role of disulfide bonds in polymer structure and performance.
- Discussion of existing literature and identification of unanswered questions.
Main Results:
- Synthetic polymers with disulfide bonds can be designed with specific architectures.
- Disulfide bonds influence polymer properties relevant to drug release and targeting.
- Several questions remain regarding the optimization and application of these systems.
Conclusions:
- Synthetic polymers with disulfide bonds represent a promising platform for drug delivery.
- Further research is needed to fully elucidate the potential of disulfide bonds in therapeutic systems.
- Understanding design principles is critical for advancing therapeutic delivery technologies.
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