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Electronics with shape actuation for minimally invasive spinal cord stimulation.

Ben J Woodington1, Vincenzo F Curto1, Yi-Lin Yu2,3

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This study introduces a novel, shape-changing spinal cord stimulation device. It offers the benefits of paddle-type devices through a minimally invasive, percutaneous needle implantation.

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Area of Science:

  • Bioelectronic devices
  • Neuromodulation therapies
  • Minimally invasive medical devices

Background:

  • Spinal cord stimulation (SCS) is a long-standing neuromodulation technique.
  • Current SCS devices present a trade-off between invasive paddle-type systems and less effective percutaneous lead systems.
  • Clinicians face challenges in selecting appropriate SCS devices due to these limitations.

Purpose of the Study:

  • To develop an innovative SCS device combining the advantages of paddle and percutaneous systems.
  • To create a minimally invasive device with a large stimulation/sensing footprint.
  • To enable in situ expansion of implanted bioelectronic devices.

Main Methods:

  • Utilized photo- and soft lithography for fabricating thin, flexible electronics with integrated fluidic channels.
  • Designed a device capable of being rolled for percutaneous needle delivery.
  • Developed a procedure for in situ device expansion to a paddle-like conformation.

Main Results:

  • Successfully developed a shape-changing bioelectronic device.
  • Demonstrated the device's ability to transition from a rolled configuration to a paddle-type conformation in situ.
  • Validated the device and implantation technique in vitro and using human cadaver models.

Conclusions:

  • The novel device offers a minimally invasive approach to SCS, overcoming the limitations of current technologies.
  • This technology enables the percutaneous implantation of large-footprint bioelectronic devices for sensing or stimulation.
  • Shape-changing bioelectronic devices represent a promising advancement in neuromodulation therapies.