Denoising of hyperpolarized ¹³ C MR images of the human brain using patch-based higher-order singular value...

To improve hyperpolarized ¹³ C (HP-¹³ C) MRI by image denoising with a new approach, patch-based higher-order singular value decomposition (HOSVD).

The benefit of using a patch-based HOSVD method to denoise dynamic HP-¹³ C MR imaging data was investigated. Image quality and the accuracy of quantitative analyses following denoising were evaluated first using simulated data of [1-¹³ C]pyruvate and its metabolic product, [1-¹³ C]lactate, and compared the results to a global HOSVD method. The patch-based HOSVD method was then applied to healthy volunteer HP [1-¹³ C]pyruvate EPI studies. Voxel-wise kinetic modeling was performed on both non-denoised and denoised data to compare the number of voxels quantifiable based on SNR criteria and fitting error.

Simulation results demonstrated an 8-fold increase in the calculated SNR of [1-¹³ C]pyruvate and [1-¹³ C]lactate with the patch-based HOSVD denoising. The voxel-wise quantification of k_PL (pyruvate-to-lactate conversion rate) showed a 9-fold decrease in standard errors for the fitted k_PL after denoising. The patch-based denoising performed superior to the global denoising in recovering k_PL information. In volunteer data sets, [1-¹³ C]lactate and [¹³ C]bicarbonate signals became distinguishable from noise across captured time points with over a 5-fold apparent SNR gain. This resulted in >3-fold increase in the number of voxels quantifiable for mapping k_PB (pyruvate-to-bicarbonate conversion rate) and whole brain coverage for mapping k_PL .

Sensitivity enhancement provided by this denoising significantly improved quantification of metabolite dynamics and could benefit future studies by improving image quality, enabling higher spatial resolution, and facilitating the extraction of metabolic information for clinical research.