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Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Updated: Nov 1, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Aggressive Mediastinal Lymphomas.

Xiaoqiong Wang¹, Wei Wang¹, Francisco Vega¹

¹Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Seminars in Diagnostic Pathology

|June 27, 2021

Summary

This summary is machine-generated.

This review covers primary mediastinal lymphomas, focusing on common and aggressive types. It details their clinical, histologic, and genetic features, aiding diagnosis of these rare thoracic malignancies.

Keywords:

Gray zone lymphoma Hodgkin lymphoma Lymphoma Mediastinal Primary mediastinal (thymic) large B-cell lymphoma T-lymphoblastic leukemia/lymphoma Thymus

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Published on: January 26, 2024

Area of Science:

Thoracic oncology
Hematopathology
Diagnostic pathology

Background:

The mediastinum houses vital organs, excluding lungs, and is susceptible to various tumors.
Lymphoma is the most frequent malignancy within the mediastinum.
Primary mediastinal lymphomas, distinct from systemic involvement, primarily affect mediastinal lymph nodes and/or the thymus.

Purpose of the Study:

To review the clinical, histologic, immunophenotypic, and molecular genetic characteristics of common and aggressive primary mediastinal lymphomas.
To provide guidance on immunohistochemistry panels for diagnosis.
To outline differential diagnoses for mediastinal lymphomas.

Main Methods:

Literature review of primary mediastinal lymphomas.
Synthesis of clinical, histologic, immunophenotypic, and molecular data.
Compilation of diagnostic immunohistochemistry panels and differential diagnoses.

Main Results:

Detailed summary of key features for prevalent and aggressive primary mediastinal lymphomas.
Recommendations for specific immunohistochemistry markers.
Guidance on distinguishing between various mediastinal lymphoma entities and other neoplasms.

Conclusions:

Accurate diagnosis of primary mediastinal lymphomas requires integrating clinical, morphologic, and molecular data.
Specific immunohistochemistry panels are crucial for accurate subtyping.
Understanding differential diagnoses is essential for appropriate patient management.