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Updated: Oct 31, 2025

Dissection and Culture of Mouse Embryonic Kidney
Published on: May 17, 2017
Ureteric Bud-derivatives in Wilms Tumor and Nephrogenic Rest
Beatrix Sarkany1, Gyula Kovacs1,2, Daniel Banyai3
1Department of Urology, Medical School, University of Pecs, Pecs, Hungary.
Background/Aim:
Recent studies suggest that not only the nephrogenic blastema but also the ureteric bud is involved in oncogenesis of Wilms' tumor (WT). However, the occurrence of ureteric bud (UB) derivatives in nephrogenic rest is not yet known. The aim of our study was to find UB derivatives in WT.
Materials And Methods:
Keratin 17 (KRT17) is expressed exclusively in UB in foetal kidneys. In this study KRT17 immunohistochemistry was used to detect UB-derivatives in 21 triphasic, 2 stromal and 3 epithelial predominant WTs and 9 nephrogenic rests.
Results:
We have detected KRT17 positive tubular structures resembling UB in 3 of 9 nephrogenic rests and 15 of 26 WTs.
Conclusion:
Not only the metanephric blastema but also the UB is involved in the histogenesis of nephrogenic rest and WT.
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