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Updated: Oct 31, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics
Sid E O'Bryant1,2, Leigh A Johnson1,2, Robert C Barber1,2
1Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Introduction:
Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature.
Methods:
Community-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository.
Results:
Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites.
Discussion:
The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.
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