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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
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Cardiorespiratory optimal point during exercise testing is related to cardiovascular and all-cause mortality
Jari A Laukkanen1,2,3, Setor K Kunutsor4,5, Claudio G Araújo6
1Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland.
Scandinavian Journal of Medicine & Science in Sports
|June 30, 2021
Summary
Cardiorespiratory optimal point (COP) during exercise is a novel marker associated with increased risk of fatal cardiovascular disease (CVD) and all-cause mortality. This finding suggests COP can enhance the prediction of long-term CVD mortality risk.
Area of Science:
- Cardiology
- Exercise Physiology
- Preventive Medicine
Background:
- Cardiopulmonary exercise testing (CPET) provides valuable clinical data.
- The prognostic significance of the cardiorespiratory optimal point (COP) for cardiovascular disease (CVD) mortality remains unclear.
Purpose of the Study:
- To investigate the association between COP during exercise and fatal mortality outcomes.
- To determine if COP can improve the prediction of CVD mortality.
Main Methods:
- Defined COP as the minimum ventilatory equivalent for oxygen (VE/VO2) during CPET in 2,205 men.
- Calculated hazard ratios (HRs) for fatal coronary heart disease (CHD), fatal CVD, and all-cause mortality during a median follow-up of 28.8 years.
- Assessed the impact of adding COP to CVD mortality risk prediction models.
Main Results:
- COP demonstrated a dose-response association with fatal CHD, fatal CVD, and all-cause mortality.
- Increased COP was linked to significantly higher mortality risk even after adjusting for established risk factors and high-sensitivity C-reactive protein.
- Incorporating COP into a CVD mortality risk model improved prediction accuracy at 25 years (C-index change = 0.0139, p=0.006).
Conclusions:
- COP during exercise is a significant independent predictor of fatal cardiovascular and all-cause mortality.
- COP may serve as a valuable tool to enhance the prediction of long-term CVD mortality risk.
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