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Updated: Oct 31, 2025

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Circular RNA Databases.

Peijing Zhang1,2, Ming Chen3,4,5

  • 1Department of Bioinformatics, State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China.

Methods in Molecular Biology (Clifton, N.J.)
|July 1, 2021
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are unique RNA molecules with closed-loop structures. This study reviews plant circRNA databases, aiding research into their biological functions and characterization.

Keywords:
DatabaseFunctionPlantResourcecircRNAmiRNA

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Circular RNAs (circRNAs) are endogenous non-coding RNAs with a distinct covalently closed-loop structure, lacking 5' caps and 3' tails.
  • Ubiquitously expressed in eukaryotes, circRNAs display cell-type, tissue, and developmental stage-specific expression patterns.
  • CircRNAs are implicated in diverse biological processes, including gene expression regulation and interactions with miRNAs and proteins.

Purpose of the Study:

  • To provide an overview of existing circRNA databases.
  • To focus on plant-specific circRNA databases and their key features.
  • To facilitate the exploration of circRNA characterization and functions.

Main Methods:

  • Literature review of circRNA databases.
  • Analysis of features and data organization within plant circRNA databases.
  • Comparative assessment of database utility for circRNA research.

Main Results:

  • Several circRNA databases (e.g., circBase, CIRCpedia, CircAtlas, circRNADb, PlantCircNet, CircFunBase) have been established.
  • These databases organize and manage vast amounts of circRNA data.
  • Plant circRNA databases offer specific resources for studying plant circRNAs.

Conclusions:

  • Existing circRNA databases are crucial for managing and exploring circRNA information.
  • Plant circRNA databases are valuable resources for advancing research in plant molecular biology.
  • Further investigation into circRNA functions can be significantly aided by these databases.