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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
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Functionalized Particles Designed for Targeted Delivery.

Teresa Basinska1, Mariusz Gadzinowski1, Damian Mickiewicz1

  • 1Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.

Polymers
|July 2, 2021
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Summary
This summary is machine-generated.

This review details advances in polymer-based nano- and microparticle drug delivery systems. It covers polymer selection, synthesis, functionalization, and loading of bioactive substances for targeted therapies.

Keywords:
functional polymermicroparticlenanoparticlenucleic acidpolymerosomeproteintargeted drug delivery

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Area of Science:

  • Polymer Science
  • Materials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Bioactive compounds often require formulation for effective medical administration.
  • Polymeric nano- and microparticles offer versatile platforms for drug delivery systems.
  • Combining active substances with polymers enhances therapeutic efficacy and targeting.

Purpose of the Study:

  • To review recent progress in polymer-based nano- and microparticle drug carriers.
  • To discuss synthesis, functionalization, and bioactive substance loading methods.
  • To highlight challenges and future directions in particle-based drug delivery.

Main Methods:

  • Overview of polymers used in nano- and microparticle drug carriers.
  • Discussion of direct synthesis of functionalized polymer particles.
  • Exploration of particle formation via self-assembly of polymers.
  • Analysis of surface modification and ligand introduction for cell targeting.
  • Review of methods for loading particles with bioactive substances.

Main Results:

  • Progress in direct synthesis and self-assembly of functional polymer particles.
  • Development of methods for introducing targeting ligands onto particle surfaces.
  • Advancements in techniques for loading particles with bioactive compounds.
  • Identification of key polymers suitable for drug carrier applications.

Conclusions:

  • Polymer nano- and microparticles are crucial for advanced drug delivery.
  • Functionalization and targeted delivery strategies are rapidly evolving.
  • Further research is needed to address remaining challenges in particle-based therapeutics.