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Updated: Oct 30, 2025
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Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
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Nitric Oxide Interaction with the Eye
Nir Erdinest1, Naomi London2, Haim Ovadia3
1Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Vision (Basel, Switzerland)
|July 2, 2021
Summary
Nitric oxide (NO) is a key messenger in the eye, influencing vision, inflammation, and healing. Understanding NO
Area of Science:
- Ophthalmology
- Physiology
- Immunology
Background:
- Nitric oxide (NO) is a crucial intercellular messenger with established roles in cardiovascular, nervous, and immune systems.
- Its prevalence and specific functions within the ocular system have been less extensively reviewed.
Purpose of the Study:
- To comprehensively review the multifaceted roles of nitric oxide (NO) within the ocular system.
- To elucidate NO's involvement in ocular homeostasis, disease pathogenesis, and therapeutic strategies.
Main Methods:
- Literature review of existing research on nitric oxide in ocular tissues and functions.
- Synthesis of findings related to NO's impact on corneal cells, retinal cells, and ocular vasculature.
Main Results:
- NO is present in corneal and retinal cells, modulating immune, inflammation, and wound-healing processes.
- NO acts as a vascular endothelial relaxant, affecting choroidal blood flow and influencing conditions like age-related macular degeneration, diabetic retinopathy, and glaucoma.
- NO's balance is critical for ocular homeostasis, impacting intraocular pressure, aqueous outflow, axial elongation, and myopia development.
Conclusions:
- Nitric oxide plays a significant and diverse role in maintaining ocular health and function.
- Dysregulation of NO contributes to various ocular pathologies, highlighting its therapeutic potential.
- Targeting NO pathways offers promising avenues for treating a range of eye diseases.
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