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Updated: Oct 30, 2025

Murine Prostate Micro-dissection and Surgical Castration
Published on: May 11, 2016
Prostate Cancer Predisposition
Yasin Bhanji1, William B Isaacs2, Jianfeng Xu3
1Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Marburg 134, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Abstract:
The identification and characterization of alterations in prostate cancer (PCa)-predisposing genes can help to inform screening strategies in undiagnosed men and treatment options in men in both the clinically localized and in the metastatic setting. This review provides an overview of the genetic basis underlying hereditary predisposition to PCa, the current role of genetics and PCa risk assessment, and how genetic risk factors affect aggressiveness and lethality of PCa.
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