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Updated: Oct 30, 2025

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The long and short of it
Lori A Passmore1, Terence Tl Tang1
1MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Elife
|July 2, 2021
Summary
Longer poly(A) tails enhance protein production during early development. However, this effect is not observed in mature cells due to higher levels of poly(A)-binding protein cytoplasmic 1 (PABPC).
Area of Science:
- Molecular and Cellular Biology
- Developmental Biology
- Gene Expression Regulation
Background:
- Polyadenylation is a crucial post-transcriptional modification affecting mRNA stability and translation.
- The poly(A) tail length is dynamically regulated and varies across different cellular contexts.
- Poly(A)-binding protein cytoplasmic 1 (PABPC) is a key regulator of mRNA translation.
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