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Related Experiment Video

Updated: Oct 30, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Patient-Reported Outcomes in Lupus.

Narender Annapureddy1, Meenakshi Jolly2

  • 1Department of Medicine, Vanderbilt University, 1160 21st Avenue, Suite T3113 MCN, Nashville, TN 37232, USA.

Rheumatic Diseases Clinics of North America
|July 3, 2021
PubMed
Summary

Patient-reported outcomes (PROs) are crucial for systemic lupus erythematosus (SLE) but are underutilized in clinical care. Recent advancements offer promising tools, yet further research is needed to integrate them into routine SLE patient management and research.

Keywords:
Patient-reported outcome (PRO)Quality of life (QOL)Systemic lupus erythematosus (SLE)

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Area of Science:

  • Rheumatology
  • Patient-Reported Outcomes
  • Systemic Lupus Erythematosus Research

Background:

  • Patient-reported outcomes (PROs) were recognized as essential for systemic lupus erythematosus (SLE) in 1999.
  • Despite this, generic PRO measures for SLE impact are primarily used in research settings.
  • Both generic and disease-specific PRO tools offer distinct benefits in assessing patient health.

Purpose of the Study:

  • To review the progress in identifying patient-relevant PRO concepts in SLE.
  • To assess the development of new PRO tools for SLE over the past two decades.
  • To highlight future research directions for PRO tool implementation in SLE care.

Main Methods:

  • Literature review of PRO identification and tool development in SLE over the last 20 years.
  • Analysis of the current utilization of generic and disease-targeted PRO measures in SLE.
  • Identification of research gaps concerning PRO tool responsiveness and clinical meaningfulness.

Main Results:

  • Significant advancements have been made in identifying patient-centered PRO concepts for SLE.
  • New PRO tools tailored for SLE have been developed.
  • Current use of generic PROs in SLE clinical practice remains limited, mainly confined to research.

Conclusions:

  • Substantial progress in SLE PRO concept identification and tool development has occurred.
  • Further research is required to establish the responsiveness and minimally important differences of existing PRO tools.
  • Facilitating the use of validated PRO tools in both SLE patient care and research is a critical next step.