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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Updated: Oct 30, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Bisphosphonates, Bone and Joint Pain.

Michel Villatoro-Villar1, C Kent Kwoh2,3

  • 1Division of Rheumatology, Department of Medicine, The University of Arizona College of Medicine, Tucson, AZ, USA.

Current Osteoporosis Reports
|July 3, 2021
PubMed
Summary
This summary is machine-generated.

Bisphosphonates show promise in treating osteoarthritis pain and inflammation by impacting bone and joint tissues. Further research is needed to confirm their clinical utility beyond osteoporosis.

Keywords:
Anti-resorptive therapyBisphosphonatesOsteoarthritisPain

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Area of Science:

  • Rheumatology
  • Pharmacology
  • Orthopedics

Background:

  • Bisphosphonates (BPs) are established treatments for osteoporosis.
  • Their efficacy in other symptomatic conditions, like osteoarthritis (OA), is less understood.

Purpose of the Study:

  • To review recent data on bisphosphonates for symptomatic bone and joint pain.
  • To examine the role of BPs in osteoarthritis (OA) as a model condition.

Main Methods:

  • Review of recent scientific literature and clinical data.
  • Analysis of studies investigating BP effects on pain, imaging, and inflammation in OA.

Main Results:

  • Bisphosphonates may improve pain ratings, imaging features, and inflammatory markers in OA patients.
  • Potential mechanisms include effects on periarticular bone, synovium, synoviocytes, and macrophages.
  • Evidence suggests BPs have extra-osteoporotic properties, particularly in conditions involving periarticular bone.

Conclusions:

  • Bisphosphonates show potential therapeutic effects beyond osteoporosis, particularly in osteoarthritis.
  • Further studies are required to define their precise role and contribution in clinical practice for OA management.