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Approximate image synthesis in optical coherence tomography.

Callum M Macdonald1, Peter R T Munro1

  • 1Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, UK.

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|July 5, 2021
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Summary
This summary is machine-generated.

Full-wave simulations for optical coherence tomography (OCT) are realistic but computationally expensive. This study introduces an approximate method to significantly reduce simulation time for OCT image formation, enabling faster volumetric data synthesis.

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Area of Science:

  • Optical physics
  • Biomedical imaging
  • Computational modeling

Background:

  • Full-wave models based on Maxwell's equations provide high fidelity OCT image formation.
  • These detailed simulations demand substantial computational resources, limiting practical application for large sample volumes.

Purpose of the Study:

  • To develop an approximate method for synthesizing volumetric OCT image formation.
  • To significantly reduce the computational burden associated with realistic OCT simulations.

Main Methods:

  • Calculated full-wave scattered light for a single normally incident plane wave.
  • Utilized angular spectrum field representation for beam focusing and scanning.
  • Employed an approximation similar to the tilt optical memory effect for volumetric synthesis.

Main Results:

  • Achieved an order of magnitude reduction in computation time for simulating OCT B-scans.
  • Demonstrated comparable results to rigorous methods when evaluating point spread functions and images.
  • Validated the approach on highly scattering structured samples for a typical OCT system.

Conclusions:

  • The proposed approximate method offers a computationally efficient alternative for OCT image simulation.
  • This technique accelerates the synthesis of volumetric OCT data sets.
  • The method provides new insights into the physics of OCT image formation.