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A mimotope attached to an ITIM-SHP-1 interaction inhibitory peptide boosts immune response and efficacy
Koushik Roy1, Syamal Roy2, Siddhartha Roy3
1Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology 4, Raja S.C.Mullick Road Kolkata 700032 India.
RSC Medicinal Chemistry
|July 5, 2021
Abstract:
Antigen binding to the B-cell receptor initiates a downstream signalling pathway that contains both stimulatory and damping components. A malarial parasite-derived conformation-constrained peptide was conjugated to a signal-damping pathway inhibitor. Mice immunized with this antigen produced higher antibody levels which delayed parasitemia. This represents a new approach to antigen design.

