Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

2.9K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
2.9K
Allergic Reactions02:06

Allergic Reactions

29.4K
Overview
29.4K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.1K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.5K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
Cross-reactivity00:42

Cross-reactivity

31.8K
Overview
31.8K
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

3.5K
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab in Difficult-to-treat Chronic Spontaneous Urticaria: A Real-world Multicentre Cohort Study.

Acta dermato-venereologica·2026
Same author

European Society of Contact Dermatitis Guideline for Diagnostic Patch Testing-Recommendations on Best Practice (Update 2026).

Contact dermatitis·2026
Same author

Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy (REIDAC).

Contact dermatitis·2026
Same author

Successful Treatment of Severe Refractory Chronic Actinic Dermatitis with Upadacitinib: A Case Series of Four Patients.

Clinical and experimental dermatology·2026
Same author

Dupilumab in patients with cold urticaria: Results from a phase 3 trial.

The journal of allergy and clinical immunology. Global·2026
Same author

Performance of omalizumab in patients with mast cell-mediated angioedema with and without wheals.

The journal of allergy and clinical immunology. In practice·2026
Same journal

Anaphylaxis: State-of-the-Art.

Immunology and allergy clinics of North America·2026
Same journal

Upending Impending Doom.

Immunology and allergy clinics of North America·2026
Same journal

Mast Cell Activation Syndrome and Mimickers.

Immunology and allergy clinics of North America·2026
Same journal

Hereditary Alpha-Tryptasemia (HαT) as a Risk Modifier for Severe Anaphylaxis.

Immunology and allergy clinics of North America·2026
Same journal

Emerging Therapies for Anaphylaxis.

Immunology and allergy clinics of North America·2026
Same journal

Novel Epinephrine Delivery Devices.

Immunology and allergy clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Oct 29, 2025

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.7K

Contact Urticaria.

Ana M Gimenez-Arnau1, Howard Maibach2

  • 1Department of Dermatology, Hospital del Mar, Universitat Autònoma de Barcelona, Passeig Maritim 25-29, Barcelona 08021, Spain.

Immunology and Allergy Clinics of North America
|July 6, 2021
PubMed
Summary
This summary is machine-generated.

Contact urticaria syndrome is often misdiagnosed. This article provides diagnostic tools and treatment strategies for healthcare professionals to identify and manage this condition effectively.

Keywords:
Contact urticariaDermatitisEczemaImmediate contact reactionImmunologyProtein contact dermatitisSyndromeUrticaria

More Related Videos

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.1K
Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

8.8K

Related Experiment Videos

Last Updated: Oct 29, 2025

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.7K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.1K
Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

8.8K

Area of Science:

  • Dermatology
  • Immunology
  • Toxicology

Background:

  • Contact urticaria syndrome (CUS) is frequently misdiagnosed due to limited physician awareness.
  • Patients often identify triggers, but novel or uncommon causes exist.
  • Understanding CUS is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To provide a comprehensive overview of contact urticaria syndrome.
  • To equip dermatologists, toxicologists, and immunologists with diagnostic tools.
  • To guide the identification and avoidance of causative agents and outline treatment plans.

Main Methods:

  • Literature review on contact urticaria syndrome.
  • Discussion of epidemiological data and occupational relevance.
  • Analysis of clinical manifestations and diagnostic approaches.

Main Results:

  • Detailed examination of CUS definition, history, and epidemiology.
  • Identification of diverse triggers including proteins, chemicals, metals, plants, and foods.
  • Elucidation of mechanisms, clinical presentations, and diagnostic methods.

Conclusions:

  • Improved recognition and diagnostic capabilities for CUS are needed.
  • Early identification and avoidance of culprit agents are key to patient management.
  • This article serves as a resource for healthcare professionals managing CUS.