Related Experiment Video
Updated: Oct 29, 2025

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Reversible regulation of metallo-base-pair interactions for DNA dehybridization by ultrasound
Shuaidong Huo1, Yu Zhou2, Zhihuan Liao3
1Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Science, Xiamen University, 361102 Xiamen, China and DWI - Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056 Aachen, Germany. herrmann@dwi.rwth-aachen.de and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Abstract:
Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by the attachment of distance-sensitive fluorescent probes and is found to be reversible.
More Related Videos
Related Concept Videos
Single-Strand DNA Binding Proteins
Homologous Recombination
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
Overview of DNA Repair
Chemically...

