Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

824
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
824
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

505
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
505

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute and Long-Term EEG and seizure characteristics in new onset refractory status epilepticus (NORSE).

Epilepsia·2026
Same author

Accuracy of the rapid-response electroencephalography's Automated Seizure Burden Estimator: A follow-up validation study of version 8 (AccuRASE II).

Epilepsia·2026
Same author

The modified Hijdra scale for prediction of delayed cerebral infarcts after subarachnoid hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Comparative Analysis of Anterior Segment Biometry: Agreement and Correlation Between Swept-Source OCT and Scheimpflug-Based Platforms.

Korean journal of ophthalmology : KJO·2026
Same author

Retraction: Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis.

The Biochemical journal·2026
Same author

Integrated chaperone engineering and process optimization enable enhanced production of ChCODH-II A559W in Escherichia coli.

World journal of microbiology & biotechnology·2026

Related Experiment Video

Updated: Oct 29, 2025

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
09:16

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

25.9K

Seizures and Cognitive Outcome After Traumatic Brain Injury: A Post Hoc Analysis.

Brandon Foreman1,2,3, Hyunjo Lee4,5, Moshe A Mizrahi4

  • 1Department of Neurology & Rehabilitation Medicine, University of Cincinnati Gardner Neuroscience Institute, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0517, USA. brandon.foreman@uc.edu.

Neurocritical Care
|July 7, 2021
PubMed
Summary

Seizures and abnormal brain patterns detected by continuous electroencephalography monitoring (cEEG) are linked to worse cognitive outcomes 3 months after moderate to severe traumatic brain injury (TBI). Early detection and treatment may improve long-term cognitive function in TBI patients.

Keywords:
CognitionContinuous electroencephalographyNeurocritical careOutcomeTraumatic brain injury

More Related Videos

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.8K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.5K

Related Experiment Videos

Last Updated: Oct 29, 2025

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
09:16

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

25.9K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.8K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.5K

Area of Science:

  • Neuroscience
  • Neurology
  • Critical Care Medicine

Background:

  • Up to 50% of patients with moderate to severe traumatic brain injury (TBI) exhibit seizures or abnormal periodic/rhythmic patterns on continuous electroencephalography monitoring (cEEG).
  • The clinical significance of these electrographic patterns on long-term cognitive function following TBI remains incompletely understood.

Purpose of the Study:

  • To investigate the association between the burden of seizures and abnormal periodic or rhythmic patterns (ictal-interictal continuum - IIC) and cognitive outcomes at 3 months post-TBI.
  • To determine if electrographic abnormalities independently predict cognitive deficits after moderate to severe TBI.

Main Methods:

  • Post hoc analysis of the INTREPID phase 2 clinical trial data (2010-2016) involving patients with moderate to severe TBI.
  • Continuous electroencephalography (cEEG) monitoring was used to quantify the burden of IIC patterns, including seizures.
  • Global cognition score at 3 months post-injury served as the primary outcome measure.

Main Results:

  • Of 142 patients, 89 underwent cEEG, with 15% showing severe IIC patterns.
  • A higher quantitative burden of IIC patterns was inversely correlated with the global cognition score (r = -0.57, p = 0.04).
  • Severe IIC patterns were independently associated with lower cognitive scores (OR 0.73, p = 0.002) after adjusting for confounders.

Conclusions:

  • The burden of seizures and abnormal periodic/rhythmic patterns on cEEG is independently associated with poorer cognitive outcomes at 3 months post-TBI.
  • Further prospective studies are warranted to explore the impact on long-term cognitive endpoints.
  • The potential benefits of early seizure detection and treatment in this patient population require investigation.