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The Monocyte to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in

Yukihiro Fukuda1, Kazuhiro Nitta1, Satoshi Kurisu1

  • 1Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences.

International Heart Journal
|July 8, 2021
PubMed

Insights

The monocyte to high-density lipoprotein cholesterol (HDL-C) ratio is linked to impaired left ventricular (LV) diastolic function in patients without perfusion abnormalities. This ratio may serve as a novel marker for assessing diastolic dysfunction using gated SPECT imaging.

Area of Science:

  • Cardiology
  • Biomarkers
  • Diagnostic Imaging

Background:

  • The monocyte to high-density lipoprotein cholesterol (HDL-C) ratio is a recognized prognostic marker.
  • Its association with left ventricular (LV) diastolic function is not well-established.
  • Investigating this relationship could reveal new insights into diastolic dysfunction.

Purpose of the Study:

  • To test the hypothesis that the monocyte to HDL-C ratio is associated with LV diastolic parameters.
  • To evaluate this association in patients without significant perfusion abnormalities using gated myocardial perfusion single-photon emission computed tomography (SPECT).

Main Methods:

  • The study included 196 patients with preserved ejection fraction and no significant perfusion abnormalities.
  • LV diastolic parameters, including peak filling rate (PFR) and one-third mean filling rate (1/3 MFR), were derived from gated SPECT.
  • Monocyte counts and HDL-C levels were measured, and the monocyte to HDL-C ratio was calculated.

Main Results:

  • A significant inverse association was found between the monocyte to HDL-C ratio and PFR (r = -0.20; P = 0.005).
  • The monocyte to HDL-C ratio was also significantly associated with 1/3 MFR (r = -0.19; P = 0.009).
  • Multivariate analysis confirmed the monocyte to HDL-C ratio as an independent factor associated with both PFR and 1/3 MFR, alongside age and LV geometry.

Conclusions:

  • The monocyte to HDL-C ratio is associated with impaired LV diastolic function in patients without significant perfusion abnormalities.
  • Gated SPECT-derived diastolic parameters are influenced by this ratio.
  • The monocyte to HDL-C ratio may represent a novel, non-invasive biomarker for assessing diastolic dysfunction.

Keywords:
InflammationMonocyte countsMyocardial imaging

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