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Updated: Oct 29, 2025

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
Dynamic Kinetic Resolution of Secondary Diols via Coupled Ruthenium and Enzyme Catalysis
B Anders Persson1, Fernando F Huerta1, Jan-E Bäckvall1
1Department of Organic Chemistry, Uppsala University, Box 531, SE-751 21 Uppsala, Sweden, and Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden.
Abstract:
Enzymatic acylation of secondary symmetrical diols (as meso/dl mixtures) in combination with ruthenium-catalyzed isomerization of the diol led to efficient dynamic kinetic resolution. In this way, a meso/dl mixture of the diol was transformed to enantiomerically pure (R,R)-diacetate, making efficient use of all the diol material. For some of the flexible substrates, substantial amounts of meso-diacetates were formed as side products. The results indicate that the major part of the meso product is formed via an intramolecular acyl-transfer pathway.
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