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COVID-19 Morbidity Among Individuals with Autistic Spectrum Disorder: A Matched Controlled Population-Based Study

Israel Krieger1, Galit Erez1, Orly Weinstein2,3

  • 1Shalvata Mental Health Center, affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Journal of Autism and Developmental Disorders
|July 9, 2021
PubMed

Insights

Individuals with Autism Spectrum Disorder (ASD) face higher COVID-19 infection rates and hospitalization risks, particularly adults aged 40-60 and men. This highlights the need for targeted public health strategies to protect this vulnerable population.

Area of Science:

  • Medical research
  • Public health
  • Neurodevelopmental disorders

Background:

  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition.
  • The impact of ASD on susceptibility to infectious diseases, including COVID-19, requires further investigation.
  • Understanding COVID-19 risks in ASD is crucial for public health policy.

Purpose of the Study:

  • To determine if individuals with ASD have higher rates of COVID-19 infection.
  • To assess if individuals with ASD are more prone to severe COVID-19 outcomes, such as hospitalization.
  • To identify demographic factors influencing COVID-19 risk within the ASD population.

Main Methods:

  • A retrospective cohort study design was employed.
  • Data from 32,812 individuals, including those with ASD and matched controls, were analyzed.
  • COVID-19 infection rates and hospitalization data were compared between groups.

Main Results:

  • Individuals with ASD exhibited significantly higher COVID-19 infection rates compared to controls.
  • The risk of infection was most pronounced in the 40-60 age group (OR=2.05).
  • Higher hospitalization odds were observed in men with ASD (OR=2.40), but not in women.

Conclusions:

  • ASD is associated with increased vulnerability to COVID-19 infection and severe illness.
  • Medical and environmental factors may contribute to these elevated risks.
  • Proactive healthcare policies are recommended to mitigate COVID-19 risks for individuals with ASD.

Keywords:
ASDAutism Spectrum DisorderCOVID-19InfectionMorbidityPopulation-based

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