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Updated: Oct 29, 2025

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Rh(I)-Catalyzed Intramolecular Decarbonylation of Thioesters
Han Cao1, Xuejing Liu1, Fusheng Bie1
1Lunan Coal Chemical Research Institute of Engineering and Technology, Zaozhuang University, 1 Bei'an Road, Zaozhuang, Shandong 277160, China.
Abstract:
Decarbonylative synthesis of thioethers from thioesters proceeds in the presence of a catalytic amount of [Rh(cod)Cl]2 (2 mol %). The protocol represents the first Rh-catalyzed decarbonylative thioetherification of thioesters to yield valuable thioethers. Notable features include the absence of phosphine ligands, inorganic bases, and other additives and excellent group tolerance to aryl chlorides and bromides that are problematic using other metals to promote decarbonylation. Gram scale synthesis, late-stage pharmaceutical derivatization, and orthogonal site-selective cross-couplings by C-S/C-Br cleavage are reported.
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