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Updated: Oct 29, 2025
Construction of an Improved Multi-Tetrode Hyperdrive for Large-Scale Neural Recording in Behaving Rats
Published on: May 9, 2018
A novel 3D-printed multi-driven system for large-scale neurophysiological recordings in multiple brain regions
Tao Sheng1, Danqin Xing2, Yi Wu3
1Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Science Center for Brain Science, Shanghai Medical School of Fudan University, Shanghai 200032, China; MOE Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu Province 210096, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.
Researchers developed a novel 3D-printed system for large-scale neural recordings. This cost-effective platform enables stable, high-density recording of brain activity in multiple regions for advanced neuroscience research.
Area of Science:
- Neuroscience
- Bioengineering
- Implantable Devices
Background:
- Electrical probes are standard for neural recordings like single-unit spike activity and local field potentials (LFPs).
- Achieving large-scale, long-term, and stable neural recordings across multiple brain regions remains challenging.
Purpose of the Study:
- To introduce a novel 3D-printed multi-drive system for high-density neural recordings.
- To enable simultaneous recording from cortical and subcortical regions in freely behaving animals.
Main Methods:
- Design and fabrication of a 3D-printed multi-drive system.
- Integration of high-density (up to 256 channels) tetrodes or grid electrodes.
- Implantation into multiple target brain areas for simultaneous recording.
Main Results:
- Successful recording of both spikes and local field potentials (LFPs).
- Acquisition of neural data from seven distinct brain regions associated with memory.
- Demonstration of stable, long-term neural activity monitoring.
Conclusions:
- The 3D-printed system offers a low-cost, large-scale solution for neural recording.
- Its flexible design and small size facilitate implantation into multiple brain areas.
- This platform represents a significant advancement for studying brain circuitry functions.
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