CORRELATION BETWEEN THE LEVELS OF ADIPOSE-DERIVED HORMONE AND CARDIOMETABOLIC MARKERS IN PATIENTS WITH HYPERTENSION...

The aim - to analyze the relationship between leptin levels and morphometric, anthropometric, biochemical parameters in patients with hypertension and obesity and in healthy individuals. The study included 64 patients with obesity and hypertension and 21 healthy individuals. The groups were comparable in age and gender. Leptin was determined by enzyme immunoassay method. Data are presented as mean values and the error of the mean (M±m). Differences were considered statistically significant at p<0,05. It was found out a strong positive correlation in the group with hypertension and obesity between plasma leptin levels and total cholesterol (r=0.40, p=0.00004), strong negative correlation between leptin and HDL (r=-0 , 43, p=0.0005), uric acid (r=0.32 p=0.00092) and ionized calcium levels (r=-0.35 p=0.00027). Leptin levels in the group of healthy individuals correlated with a waist circumference (r=0.78, p=0.005), BFM, BMI and age (r=0.92, r=0.94, r=0.81, p<0 , 05), uric acid levels (r=0.94) and ionized calcium (r=0.91) at p<0.05. The present study provides evidence that BFM, TG, HDL, VLDL, atherogenic index, ionized calcium levels and uric acid have a significant impact on serum leptin in patients with hypertension and obesity.