[MORPHOLOGICAL CHANGES IN THE SKIN OF GUINEA PIGS AFTER THE IMPACT OF LOCAL UVA EXPOSURE]

It seems that safety of the impact of the UVA on the skin is associated with insidious identifying of early manifestation of damage and distant consequences of impact on the skin and the whole organism. The imagination of safety of UVA exposure has led to wide spread of radiator of UV rays of range A. This scientific research was devoted to identifying of positive and negative impact of UVA on the skin. The aim of the study was to investigate the morphological and functional state of the guinea pigs' skin under the influence of local fractional UVA radiation. Materials and methods. Studies were conducted on albino guinea pigs that weight 300-350 g. The local fractional regime of exposure was obtained by UV radiator OUFK-03, which generates mainly UVA radiation with the aim of creating the model of exposure in the most similar to real conditions. The shaved area (2x2 cm) of animals' skin (n=6) was exposed for 30 minutes for 5 days. Guinea pigs were located in a distance of 10 centimeters from the source of exposure. Experiments with animals were finished on the 6-th day after exposure. All animals were deduced from the experiment with the help of general anesthesia keeping the principles of bioethics with the aim of investigation of peculiarities of morphological changes of skin. Visible changes in the morphological and functional state of the skin were detected on the 6-th day after irradiation: signs of acute inflammation and a tendency to chronicity of the process, multiple, compared with normal, thickening of the epidermis, degenerative changes in epidermocytes, hyper- and parakeratosis, focal destructive changes in connective tissue fibers in the dermis, which are accompanied by reactive inflammatory processes. Signs of starting reparative processes in proliferative form of functional active fibroblasts and increasing of collagenogenesis at sites of damage of collagen and elastin fibers are market simultaneously. It is considered that the negative effects of UVA in studied regime on the skin, the task of developing of depending actions is to reduce negative UVA impact which will be the aim of our next researches.