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Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
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[Reflux nephropathy in children: pathogenesis and prognosis. Part 1]
O L Morozova1, D Y Lakomova2, N B Zakharova2
1Sechenov First Moscow State Medical University, Moscow, Russia, Moscow, Russia.
Urologiia (Moscow, Russia : 1999)
|July 12, 2021
Summary
Vesicoureteral reflux (VUR) is a common condition in children that can lead to reflux nephropathy (RN) and chronic kidney disease (CKD). This review analyzes VUR treatments to prevent RN and preserve kidney function.
Area of Science:
- Pediatric Nephrology
- Urology
- Pediatric Urology
Background:
- Vesicoureteral reflux (VUR) is the most common pediatric urodynamic abnormality.
- Reflux nephropathy (RN) is a leading cause of chronic kidney disease (CKD) in children.
- Understanding VUR's impact on renal health is crucial for early intervention.
Purpose of the Study:
- To review current literature on renal damage from VUR.
- To identify risk factors for RN development and progression.
- To evaluate treatment strategies for VUR and associated urinary tract infections.
Main Methods:
- Comprehensive literature search on VUR and RN.
- Analysis of risk factors for RN.
- Review of conservative and surgical VUR treatment options.
- Examination of morphological aspects of RN.
Main Results:
- VUR is a primary cause of RN and subsequent CKD.
- Risk factors influencing RN progression are identified.
- Both conservative and surgical interventions aim to prevent RN.
- Morphological changes in RN formation are detailed.
Conclusions:
- Effective management of VUR is essential to prevent RN.
- Treatment strategies focus on eradicating reflux and infection.
- Timely intervention improves the prognosis of RN.
- Understanding RN pathogenesis aids in prevention and management.
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