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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Respiratory syncytial virus bronchiolitis among refugees and asylum seekers from war-torn countries
Moran Lavie1, Dror Maymon1, Nir Diamant1
1Pediatric Pulmonology Unit, Dana-Dwek Children's Hospital, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Insights
Refugee infants with respiratory syncytial virus (RSV) bronchiolitis experienced longer hospital stays and needed more nutritional support. This suggests a more severe disease course in this vulnerable population compared to local children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Bronchiolitis is a significant childhood illness, particularly in developing nations.
- Assessing bronchiolitis severity in refugee and asylum-seeking children is crucial due to their origins in high-burden countries.
Purpose of the Study:
- To evaluate the severity of respiratory syncytial virus (RSV) bronchiolitis in infants and toddlers who are refugees and asylum seekers.
- To compare the disease course and healthcare needs of refugee children with those of children in a developed country.
Main Methods:
- A retrospective cohort study compared 92 refugee children (0-24 months) with 93 Israeli children diagnosed with RSV bronchiolitis.
- Data collected from 2009-2017 included length of stay (LOS), nutritional support requirements, and clinical characteristics.
- The study utilized a comparative group design, contrasting a refugee population from developing countries with a control group from a developed country.
Main Results:
- Refugee children had a significantly longer mean length of stay (4.7 days) compared to controls (3.5 days).
- Hospitalized refugee children were more likely to require nutritional support (48%) than controls (24%).
- No significant differences were observed in vital signs, physical findings, symptoms, laboratory results, or complications between the groups.
Conclusions:
- Refugee and asylum-seeking children experienced a more prolonged RSV bronchiolitis illness course.
- These children required more nutritional support, indicating potentially greater disease severity.
- Findings highlight the increased burden of RSV bronchiolitis in vulnerable refugee populations.
Background:
Bronchiolitis is a prominent illness in children with a high burden in the developing world. Our objective was to assess bronchiolitis severity among infants and toddlers of refugees and asylum seekers who fled from developing countries with high disease burden to a developed country.
Study Design:
A retrospective cohort comparative-group study of children 0-24 months of age who were admitted with a diagnosis of respiratory syncytial virus (RSV) bronchiolitis to a tertiary university-affiliated medical center during 2009-2017. The refugees and asylum seekers (study group) were mostly from war-torn African countries, and the control group was comprised of children from Israel (controls), a developed country. The primary outcome was length of stay (LOS), and the secondary outcomes were nutritional support and disease characteristics.
Results:
A total of 185 patients were included (92 refugees and 93 controls). The mean LOS was higher for the former compared to the latter (4.7 ± 3.2 vs. 3.5 ± 2 days, respectively, p = .004). More hospitalized refugees required nutritional support compared to controls (48% vs. 24%, respectively, p = .002). No differences were found in vital signs, physical findings and symptoms, laboratory results, or complications.
Conclusions:
Refugees and asylum seekers from developing countries presented with a longer RSV bronchiolitis disease course and required more nutritional support compared to their Israeli counterparts. This may suggest a more severe disease.
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