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Updated: Oct 28, 2025

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One-Pot Synthesis of Aryl Selenonic Acids and Some Unexpected Byproducts
Kai N Sands1, Benjamin S Gelfand1, Thomas G Back1
1Department of Chemistry, University of Calgary, Calgary, Alberta, Canada T2N 1N4.
Abstract:
The synthesis of aryl selenonic acids was achieved from diverse aryl bromides via a one-pot method involving metalation, selenation, and oxidation with hydrogen peroxide followed by ion exchange to afford the pure products in 77-90% yield. An o-hydroxymethyl derivative was found to dehydrate readily, affording the first example of a cyclic selenonic ester, while two minor byproducts were isolated and shown by X-ray crystallography to be mixed salts of aryl selenonic acids with either the corresponding aryl seleninic or selenious acid.
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