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Circumscribed palmoplantar hypokeratosis.
1Department of Dermatology, Ed. Herriot Hospital, Lyon, France.
Clinics in Dermatology
|July 17, 2021
Summary
Circumscribed palmoplantar hypokeratosis (CPH) is a rare skin condition affecting palms, characterized by distinct plaques. While its cause is unclear, surgical excision offers the best results for this benign condition.
Area of Science:
- Dermatology
- Pathology
Background:
- Circumscribed palmoplantar hypokeratosis (CPH) is a rare acquired dermatosis.
- First described in 2002, it primarily affects middle-aged to elderly women on the palms.
Purpose of the Study:
- To review the clinical and microscopic features of CPH.
- To discuss proposed pathogenetic mechanisms and therapeutic options.
Main Methods:
- Review of existing literature and case reports.
- Analysis of clinical and histopathological findings.
Main Results:
- CPH presents as sharply demarcated, annular erythematous plaques with a depressed center and raised keratotic border.
- Microscopically, it shows a significant decrease in horny layer thickness with minimal associated changes.
- Proposed causes include epidermal malformation, differentiation/keratinization disorders, HPV, or trauma.
Conclusions:
- CPH has a characteristic clinical and microscopic appearance but remains poorly understood.
- Surgical excision yields the best therapeutic results, though intervention is optional due to its benign nature.
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