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Reply to: Does Total Neoadjuvant Treatment Improve Overall Survival in Rectal Cancer? No, It Does Not

Joseph C Kong1,2, Sam Ngan3,4, Jeanne Tie3,5

  • 1Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. joekong@gmail.com.

Annals of Surgical Oncology
|July 18, 2021
PubMed
Abstract

No abstract available in PubMed .

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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