Related Experiment Video
Updated: Oct 28, 2025
09:02
Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
1.7K
Epistaxis: the cause found beyond the nose
Rahul Verma1, Vinay Nagaraja Gowda1, Ashok Singh1
1All Institute of Medical Science Rishikesh, Department of Pathology. Rishikesh, Uttarakhand, India.
Autopsy & Case Reports
|July 19, 2021
Summary
Metastatic renal cell carcinoma (RCC) rarely affects the head and neck, particularly the paranasal sinuses. This case highlights the importance of considering RCC metastasis in asymptomatic patients with unexplained nasal masses.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Renal cell carcinoma (RCC) is a kidney malignancy often diagnosed at a metastatic stage.
- Head and neck metastases account for up to 3% of metastatic RCC cases.
- The paranasal sinuses are an exceptionally rare site for RCC metastasis.
Observation:
- A 74-year-old female presented with a traumatic nasal bleed.
- Imaging revealed a fronto-ethmoidal mass with pachymeningeal involvement.
- Histopathology confirmed metastatic clear cell carcinoma, identified as RCC via immunohistochemistry.
Findings:
- Radiological examination identified an asymptomatic, exophytic mass in the kidney.
- The patient had no renal complaints, making the metastasis unexpected.
- This represents a rare instance of asymptomatic metastatic RCC to the fronto-ethmoidal sinus.
Implications:
- Considering metastatic RCC in the differential diagnosis for unexplained head and neck masses is crucial.
- Early detection of rare metastatic sites can lead to timely treatment.
- Prompt diagnosis and management of metastatic RCC can improve patient survival rates.
More Related Videos
Related Concept Videos
01:30Epistaxis
302
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
302
01:24Nose and Nasal Cavity
6.1K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
6.1K
01:24Esophageal Varices-I: Introduction
507
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
507
01:22Esophageal Perforation-I: Introduction
213
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
213
01:29Anatomy of Respiratory System I: Upper Respiratory Tract
3.2K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
3.2K
01:03Olfactory Receptors: Location and Structure
9.9K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.9K