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Updated: Oct 27, 2025

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Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
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Can Transcranial Direct Current Stimulation Enhance Functionality in Older Adults? A Systematic Review
Andrés Pino-Esteban1, Álvaro Megía-García1,2, David Martín-Caro Álvarez1
1Toledo Physiotherapy Research Group (GIFTO), Faculty of Physiotherapy and Nursing, Castilla La Mancha University, 13001 Toledo, Spain.
Journal of Clinical Medicine
|July 19, 2021
Summary
Transcranial direct current stimulation (tDCS) can improve balance and posture in healthy older adults. This non-invasive brain stimulation technique shows promise, but more research is needed to confirm optimal protocols.
Area of Science:
- Neuroscience
- Gerontology
- Rehabilitation Science
Background:
- Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique.
- Its efficacy requires further assessment across diverse populations and clinical uses.
- Older adults may benefit from interventions to maintain or improve functionality.
Purpose of the Study:
- To systematically review evidence on tDCS effects on functionality in adults over 60.
- To summarize findings from randomized clinical trials comparing tDCS to sham stimulation.
Main Methods:
- Systematic literature search for randomized clinical trials of tDCS in older adults.
- Inclusion of studies without publication date restrictions.
- Analysis of nine high-quality studies involving 260 healthy participants (aged 61-85.8 years).
Main Results:
- Seven out of nine studies reported significant functional improvements with tDCS compared to sham.
- Anodal tDCS over the motor cortex showed potential for enhancing balance and posture control.
- Improvements were noted in various functionality variables.
Conclusions:
- tDCS, particularly anodal stimulation of the motor cortex, may effectively improve balance and posture in healthy older adults.
- Further high-quality randomized controlled trials are necessary.
- Optimal tDCS protocols and broader benefits for older adults require clarification.

