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[Schizophrenia and cardiometabolic disorders]

G V Rukavishnikov1, E D Kasyanov1, T V Zhilyaeva2

  • 1Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 20, 2021
PubMed

Insights

This review explores the biological links between schizophrenia and metabolic/cardiovascular diseases. Understanding these shared mechanisms can lead to new treatments and a better grasp of disease origins.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Internal Medicine

Background:

  • Schizophrenia frequently co-occurs with metabolic and cardiovascular diseases.
  • These comorbidities are not solely explained by external risk factors, suggesting shared underlying biological mechanisms.
  • Investigating these shared pathways is crucial for understanding disease etiology.

Purpose of the Study:

  • To analyze the fundamental biological mechanisms underlying the comorbidity of schizophrenia and metabolic/cardiovascular diseases.
  • To explore the pathophysiological links between schizophrenia and somatic disorders.
  • To highlight the relevance of integrated genetic and molecular research approaches.

Main Methods:

  • Literature review focusing on biological mechanisms.
  • Analysis of pathophysiological pathways.
  • Examination of genetic and molecular research findings.

Main Results:

  • Schizophrenia may be a heterogeneous disorder with varied genetic underpinnings.
  • Shared neuroendocrine and inflammatory processes likely contribute to comorbid somatic disorders.
  • Integrated research approaches are essential for unraveling these complex relationships.

Conclusions:

  • Understanding shared biological mechanisms is key to developing novel therapeutic and diagnostic strategies for schizophrenia and its associated metabolic/cardiovascular diseases.
  • Further research integrating genetic and molecular methods is warranted.
  • This integrated approach will enhance the understanding of disease etiopathogenesis.

Keywords:
biological comorbiditycardio-vascular diseasesmetabolic abnormalitiesone-carbon metabolismschizophrenia

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