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The Types and Proportions of Commensal Microbiota Have a Predictive Value in Coronary Heart Disease

Lin Chen1,2, Tomoaki Ishigami1, Hiroshi Doi1

  • 1Department of Medical Science and Cardio-Renal Medicine, Graduate School of Medicine, Yokohama City University, Kanagawa 236-0027, Japan.

Journal of Clinical Medicine
|July 24, 2021
PubMed

Insights

This study reveals specific gut bacteria linked to coronary heart disease (CHD). Findings highlight Bacteroides, Prevotella, and Firmicutes as common in CHD patients, suggesting a role for the gut microbiome in cardiovascular health.

Area of Science:

  • Microbiome research
  • Cardiovascular disease
  • Gut microbiota

Background:

  • Emerging evidence suggests a link between gut microbiota and atherosclerotic cardiovascular disease.
  • Previous research indicates the importance of commensal microbiota in cardiovascular health.
  • A comprehensive analysis specifically for coronary heart disease (CHD) was lacking.

Purpose of the Study:

  • To systematically review and analyze prospective observational studies on the association between commensal microbiota and CHD.
  • To identify specific types of commensal microbiota associated with the presence and progression of CHD.

Main Methods:

  • Systematic review of published literature.
  • Inclusion of 16 cohort studies with data from 2210 patients.
  • Meta-analysis of identified studies to synthesize findings on microbiota composition.

Main Results:

  • Bacteroides and Prevotella were frequently found in fecal samples of CHD patients.
  • Firmicutes were also commonly identified in the gut microbiota of individuals with CHD.
  • Specific bacteria like Veillonella, Proteobacteria, Streptococcus, and Clostridium were found across plaque, blood, and fecal samples.

Conclusions:

  • Several commensal microbiota types are significantly associated with coronary heart disease.
  • The presence and abundance of these bacteria may correlate with established disease markers.
  • Further research into the gut microbiome's role in CHD pathogenesis is warranted.

Keywords:
commensal microbiotacoronary heart diseasesystematic review

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