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Updated: Oct 26, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Contralateral protective effect against repeated bout of damaging exercise: A meta-analysis
Sunggun Jeon1, Minsoo Kang2, Xin Ye3
1School of Kinesiology, Applied Health and Recreation, Applied Neuromuscular Physiology Laboratory, Oklahoma State University, Stillwater, OK, USA.
An initial bout of exercise protects the contralateral limb muscles from damage in subsequent exercise. This contralateral protective effect is influenced by the duration between exercise bouts, particularly within six weeks.
Area of Science:
- Exercise Physiology
- Sports Science
- Muscle Physiology
Background:
- The contralateral protective effect (CL-RBE) describes how an initial bout of exercise can protect the contralateral limb from muscle damage in a subsequent bout.
- Understanding the factors influencing CL-RBE is crucial for optimizing training protocols and injury prevention.
Conclusions:
- The findings demonstrate that an initial exercise bout confers a protective effect on contralateral limb muscles against subsequent muscle damage.
- The magnitude of this contralateral protective effect is dependent on the time interval between exercise bouts, with shorter durations (≤6 weeks) showing a notable influence.
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