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Updated: Oct 26, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.9K

Pediatric Myelodysplastic Syndromes

Sanjay S Patel1

  • 1Division of Hematopathology, Weill Cornell Medical College/NewYork-Presbyterian Hospital, 525 East 68th Street, Starr 711A, New York, NY 10065, USA.

Clinics in Laboratory Medicine
|July 26, 2021
PubMed

Insights

Pediatric myelodysplastic syndromes (MDS) are rare childhood cancers, often linked to genetic factors or prior chemotherapy. Diagnosis requires thorough clinical and lab evaluation, including advanced genetic sequencing.

Area of Science:

  • Pediatric Hematology Oncology
  • Cancer Genetics
  • Clinical Diagnostics

Background:

  • Pediatric myelodysplastic syndromes (MDS) represent a rare group of childhood hematologic malignancies, accounting for less than 5% of all childhood cancers.
  • A significant proportion, 30% to 45%, of pediatric MDS cases are linked to underlying genetic predisposition syndromes.
  • Some children develop MDS or acute myeloid leukemia (AML) after intensive chemotherapy for other malignancies.

Purpose of the Study:

  • To review the clinical subtypes of pediatric MDS.
  • To discuss the current diagnostic criteria and schema for pediatric MDS.
  • To present findings from recent next-generation sequencing studies in pediatric MDS.

Main Methods:

  • Comprehensive clinical evaluation of pediatric MDS patients.
  • Laboratory-based diagnostic assessments, including ancillary testing.
  • Application of next-generation sequencing (NGS) technologies.

Main Results:

  • MDS diagnosis in children necessitates a detailed clinical and laboratory workup.
  • Genetic predisposition syndromes are frequently associated with pediatric MDS.
  • NGS studies are increasingly contributing to the understanding of pediatric MDS.

Conclusions:

  • Accurate diagnosis of pediatric MDS relies on integrated clinical and laboratory data.
  • Genetic factors play a crucial role in the pathogenesis of many pediatric MDS cases.
  • Next-generation sequencing offers valuable insights into the molecular landscape of pediatric MDS.
Keywords:
DysplasiaInherited bone marrow failureMDSMyelodysplastic syndromeStem cell transplant

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