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Pediatric Myeloproliferative Neoplasms

Farah El-Sharkawy1, Elizabeth Margolskee2

  • 1Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Clinics in Laboratory Medicine
|July 26, 2021
PubMed

Insights

Pediatric myeloproliferative neoplasms are rare and challenging to diagnose. This review covers diagnosis, prognosis, and therapy for childhood chronic myeloid leukemia, essential thrombocythemia, polycythemia vera, and primary myelofibrosis.

Area of Science:

  • Hematology
  • Pediatric Oncology

Background:

  • Myeloproliferative neoplasms (MPNs) are a group of disorders that can occur in children.
  • Diagnosis, prognosis, and therapy for pediatric MPNs are not well-established.
  • This review focuses on specific MPNs in children.

Purpose of the Study:

  • To provide a comprehensive overview of pediatric myeloproliferative neoplasms.
  • To discuss the diagnostic challenges, prognostic factors, and therapeutic strategies for these conditions in children.

Main Methods:

  • Literature review focusing on pediatric myeloproliferative neoplasms.
  • Synthesis of current knowledge on diagnosis, prognosis, and therapy.
  • Discussion of specific MPN subtypes in the pediatric population.

Main Results:

  • Pediatric MPNs can present unique diagnostic and therapeutic challenges.
  • Specific considerations for chronic myeloid leukemia, essential thrombocythemia, polycythemia vera, and primary myelofibrosis in children are highlighted.
  • Limited research exists specifically for pediatric MPNs.

Conclusions:

  • Early diagnosis and tailored therapy are crucial for improving outcomes in pediatric MPNs.
  • Further research is needed to better understand and manage these rare conditions in children.
  • This review serves as a resource for clinicians managing pediatric MPNs.

Keywords:
Chronic myeloid leukemiaEssential thrombocythemiaMyeloproliferative neoplasmsPediatricsPolycythemia veraPrimary myelofibrosis

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