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Squamoid Eccrine Ductal Carcinoma.

Steven A Svoboda1, Patrick S Rush1, Craig J Garofola1

  • 1Drs. Svoboda, Rush, Grider, Prickett, and Phillips are from Virginia Tech Carilion School of Medicine, Roanoke. Drs. Rush, Grider, Prickett, and Phillips are from the Section of Dermatology, Department of Internal Medicine. Drs. Rush and Grider also are from the Department of Basic Science Education. Dr. Garofola is from the Department of Dermatology, LewisGale Hospital Montgomery, Blacksburg, Virginia.

Cutis
|July 27, 2021
PubMed
Summary
This summary is machine-generated.

Squamoid eccrine ductal carcinoma (SEDC), a rare skin cancer, is often misdiagnosed. Mohs micrographic surgery (MMS) effectively treats SEDC, with no recurrences observed in a recent study.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Squamoid eccrine ductal carcinoma (SEDC) is a rare primary cutaneous tumor.
  • It presents a biphasic histologic appearance, often leading to misdiagnosis as squamous cell carcinoma (SCC) on initial biopsy due to superficial sampling.
  • SEDC has a high risk of local recurrence and metastasis.

Purpose of the Study:

  • To review the clinical and histologic details of patients with SEDC treated with Mohs micrographic surgery (MMS).
  • To evaluate the efficacy of MMS in managing SEDC and distinguish it from SCC.
  • To support MMS as the preferred treatment for SEDC.

Main Methods:

  • Review of 5 patients with SEDC treated with MMS between November 2018 and May 2020.
  • Analysis of clinical and histologic features, including immunohistochemical markers (CEA, EMA, CK 5/6, p63).
  • Evaluation of treatment outcomes, recurrence rates, and metastasis after a mean follow-up of 11 months.

Main Results:

  • All 5 patients with SEDC treated with MMS achieved complete tumor clearance.
  • Multiple Mohs stages were required for complete tumor removal in all cases.
  • No evidence of recurrence or metastasis was observed during the follow-up period.

Conclusions:

  • Mohs micrographic surgery (MMS) is the treatment of choice for squamoid eccrine ductal carcinoma (SEDC).
  • MMS allows for complete tumor clearance and minimizes the risk of recurrence and metastasis.
  • Accurate histologic examination and immunohistochemistry are crucial for diagnosing SEDC and differentiating it from SCC.