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Behavioral tests in rodent models of stroke
1Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 240 W Green Street, Athens, GA, USA.
Brain Hemorrhages
|July 29, 2021
Summary
Rodent models are crucial for stroke research, but assessing cognitive function remains challenging. This review details behavioral tests for evaluating stroke outcomes in rodents, enhancing translational potential.
Area of Science:
- Neuroscience
- Translational Medicine
- Animal Models
Background:
- Rodents are widely used in stroke research due to anatomical similarities and genetic availability.
- Assessing higher brain functions like cognition and memory in rodents is difficult, limiting study translatability.
Purpose of the Study:
- To review commonly used behavioral tests for assessing motor, sensorimotor, and cognitive functions in rodent stroke models.
- To compare the application and effectiveness of these tests in both ischemic and hemorrhagic stroke models.
- To discuss the advantages and disadvantages of various behavioral tests for stroke outcome evaluation.
Main Methods:
- Literature review of established behavioral tests in rodent stroke research.
- Categorization of tests based on assessed function (motor, sensorimotor, cognition).
- Analysis of test applicability across different stroke types (ischemic and hemorrhagic).
Main Results:
- Commonly used motor/sensorimotor and cognition tests are summarized.
- The application of each test in ischemic and hemorrhagic stroke models is detailed.
- Advantages and limitations of each test for stroke outcome assessment are discussed.
Conclusions:
- Behavioral tests are essential for evaluating stroke outcomes in rodent models.
- Understanding the strengths and weaknesses of each test is critical for improving translational research.
- Standardized and validated cognitive tests are needed to enhance the assessment of higher brain functions in rodent stroke studies.
