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Updated: Oct 26, 2025
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The Mouse Hindbrain As a Model for Studying Embryonic Neurogenesis
Published on: January 29, 2018
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Segmentation and patterning of the vertebrate hindbrain.
Robb Krumlauf1,2, David G Wilkinson3
1Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Development (Cambridge, England)
|July 29, 2021
Summary
The hindbrain segments (rhombomeres) are formed by gene regulatory networks. Boundary cells play roles in patterning and neurogenesis, sharpening segment identity during development.
Area of Science:
- Developmental Biology
- Neuroscience
- Genetics
Background:
- The hindbrain is segmented into rhombomeres, crucial for neural and craniofacial organization.
- Gene regulatory networks establish anteroposterior identity in these segments.
Purpose of the Study:
- To review the conserved regulatory cascade in hindbrain segmentation.
- To explain pattern sharpening and stabilization mechanisms.
- To discuss the role of boundary cells in patterning and neurogenesis.
Main Methods:
- Review of existing literature on hindbrain development.
- Analysis of gene regulatory networks and signaling pathways.
- Examination of dynamic cell identity regulation and cell segregation.
Main Results:
- Gene regulatory networks precisely pattern hindbrain segments.
- Dynamic regulation of cell identity and segregation sharpen segment borders.
- Specialized boundary cells emerge at segment borders.
Conclusions:
- Hindbrain segmentation is a conserved process involving gene regulation and cell dynamics.
- Boundary cells are critical for local patterning and serve as neurogenic sites within the hindbrain.
Keywords:
Anteroposterior patterningBoundary formationCell segregationHindbrain segmentationNeurogenesisMore Related Videos
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