Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Folding

Protein Folding

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of a multiplex respiratory PCR panel on antibiotic stewardship in hospitalized pediatric pneumonia: a randomized clinical trial.

European journal of pediatrics·2026

Same author

Dissecting age-specific genetic architecture of vitiligo through integrative Post-GWAS analysis.

Frontiers in immunology·2026

Same author

Bioengineered Probiotic-Prebiotic Hierarchical Microspheres With pH-Responsive Architecture Reprogram Immunometabolism in Obesity-Related Disorders.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Functional biomaterials for the treatment of periprosthetic joint infection: A systematic review of preclinical animal studies.

Journal of orthopaedic translation·2026

Same author

Corrigendum "chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L." [Biomedicine & Pharmacotherapy 166 (2023) 115315].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Same author

Cationic microparticles inhibit local sterile inflammation in tissue injuries.

Regenerative biomaterials·2026

Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-syn ergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026

Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026

Same journal

Enhanced Antithrombogenic Performance of Microfluidic Oxygenators through Dual Bioactive Surface Modification for an Artificial Placenta System.

Acta biomaterialia·2026

Same journal

Interface engineering to enhance properties of bioprosthetic heart valve materials with polysaccharide nanocomposite-conjugated hydrogels.

Acta biomaterialia·2026

Same journal

Thermoresponsive hydrogel for long-acting delivery of structurally intact and biologically active Fab fragment and monoclonal antibody.

Acta biomaterialia·2026

Same journal

Cell crowding initiates tumor invasion by triggering a nanoscale topography transition of plasma membranes.

Acta biomaterialia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 26, 2025

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Deciphering and engineering tissue folding: A mechanical perspective.

Yanlun Zhu¹, Shuai Deng¹, Xiaoyu Zhao²

¹Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; Key Laboratory for Regenerative Medicine of the Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

Acta Biomaterialia

|July 29, 2021

Summary

This summary is machine-generated.

Tissue folding is crucial for organism development and function. This review explores the mechanical forces driving tissue folding and in vitro engineering strategies for tissue regeneration.

More Related Videos

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Published on: May 21, 2018

Author Spotlight: Non-Contact Measurement of Tissue Mechanics in Live Chick Embryos Using Brillouin Microscopy

Author Spotlight: Non-Contact Measurement of Tissue Mechanics in Live Chick Embryos Using Brillouin Microscopy

Published on: November 10, 2023

Related Experiment Videos

Last Updated: Oct 26, 2025

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Published on: May 21, 2018

Author Spotlight: Non-Contact Measurement of Tissue Mechanics in Live Chick Embryos Using Brillouin Microscopy

Author Spotlight: Non-Contact Measurement of Tissue Mechanics in Live Chick Embryos Using Brillouin Microscopy

Published on: November 10, 2023

Area of Science:

Developmental Biology
Biophysics
Tissue Engineering

Background:

Tissue folding is a fundamental biological process essential for structural and functional development in multicellular organisms.
Historically, research focused on biochemical signaling, but mechanical aspects are now gaining prominence.
Understanding tissue folding mechanics is key to advancing tissue engineering and regenerative medicine.

Purpose of the Study:

To review recent findings on the mechanical aspects of tissue folding.
To introduce in vitro strategies for controlling and recapitulating tissue folding.
To provide a perspective on translating these findings to clinical applications.

Main Methods:

Focus on mechanical effects at cellular and tissue levels.
Review of cell-based and biomaterial-based approaches for recapitulating folding.
Analysis of in vitro folding control strategies.

Main Results:

Mechanical forces play a significant role in triggering tissue folding.
Various cell- and biomaterial-based methods can be used to engineer folded tissues in vitro.
Controlled mechanical cues can guide tissue morphogenesis.

Conclusions:

Mechanical principles are vital for understanding and engineering tissue folding.
In vitro recapitulation of folding holds promise for tissue engineering.
Further development is needed for preclinical and clinical translation of biofabrication technologies.