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RNA-binding proteins modulate drug sensitivity of cancer cells

Oliver Rogoyski1, André P Gerber1

  • 1Department of Microbial Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, U.K.

Emerging Topics in Life Sciences
|July 30, 2021
PubMed

Insights

The RNA binding protein (RBP) interactome offers new therapeutic targets for diseases. It also influences how cancers respond to chemotherapy, impacting treatment effectiveness.

Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Gene expression is regulated by complex networks.
  • RNA binding proteins (RBPs) play crucial roles in these networks.
  • The RBP interactome is increasingly recognized for its links to disease.

Purpose of the Study:

  • To highlight the role of the RBP interactome in modulating therapeutic responses.
  • To provide examples of RBP-mediated modulation of chemotherapeutic sensitivity in cancers.

Main Methods:

  • Review of current literature on RBP interactome and disease.
  • Analysis of studies demonstrating RBP influence on drug sensitivity.
  • Case examples illustrating RBP modulation of chemotherapy.

Main Results:

  • The RBP interactome contains numerous disease-associated targets.
  • Evidence shows RBPs can alter cancer cell response to chemotherapeutics.
  • Specific examples demonstrate modulation of chemotherapeutic sensitivity.

Conclusions:

  • The RBP interactome is a promising area for therapeutic development.
  • Understanding RBP roles can optimize existing cancer treatments.
  • Targeting RBPs may enhance chemotherapeutic efficacy.
Keywords:
RNA-binding proteinschemotherapy resistanceinteractomicsposttranscriptional regulation

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