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Updated: Oct 26, 2025
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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
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Gut microbiota: a target for intervention in obesity
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Expert Review of Gastroenterology & Hepatology
|July 30, 2021
Summary
The gut microbiome influences obesity, but more research is needed. Microbiota restoration therapies for obesity are promising but currently limited to research settings.
Area of Science:
- Microbiome research
- Obesity pathogenesis
- Therapeutic interventions
Background:
- Obesity is a growing global health issue.
- Gut microbiota composition is increasingly linked to obesity.
- Microbiota restoration therapies are emerging as potential obesity management strategies.
Purpose of the Study:
- To review the role of gut microbiota in obesity.
- To explore microbiota-based therapies for obesity management.
- To present current data on microbiome markers and future therapeutic directions.
Main Methods:
- Literature search of PubMed (inception–August 2020).
- Keywords: gut microbiota, gut microbiome, microbiota, microbiome, obesity, obesity and fecal microbiota transplantation.
- Review of obesity pathogenesis, gut microbiota-obesity relationship, and microbiota-based therapies.
Main Results:
- Gut microbiota plays a role in obesity pathogenesis.
- Microbiota-based therapies show potential but require further investigation.
- Human studies are scarce, limiting current therapeutic applications.
Conclusions:
- The direct causal link between gut microbiota and obesity requires more research.
- Microbiota restoration for obesity should be confined to research settings currently.
- Future research should focus on adjunct therapies and personalized treatments based on bacterial strains and metabolic profiles.
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