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Psoriasis beyond the skin: Ophthalmological changes (Review)
Maria-Magdalena Constantin1,2, Maria-Diana Ciurduc2, Stefana Bucur1,2
1Third Department, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Experimental and Therapeutic Medicine
|August 4, 2021
Summary
Psoriasis patients, whether on treatment or not, require regular eye exams. Early detection of ocular complications like uveitis is crucial for managing this immune-mediated inflammatory disease and preventing vision loss.
Area of Science:
- Dermatology
- Ophthalmology
- Immunology
Background:
- Psoriasis is a chronic, immune-mediated inflammatory disease with unknown causes, potentially linked to T-lymphocyte dysfunction.
- Ocular manifestations are common in psoriasis, especially psoriatic arthritis and pustular psoriasis, often affecting men during disease flares.
- Eye complications can manifest later than skin or joint issues, with blindness being a severe risk.
Purpose of the Study:
- To review the ophthalmic manifestations associated with psoriasis.
- To highlight the role of systemic inflammation and psoriasis treatments in causing ocular changes.
- To emphasize the necessity of regular eye examinations for all psoriasis patients for timely diagnosis and management.
Main Methods:
- Review of existing literature on ocular manifestations in psoriasis.
- Analysis of potential etiopathogenic mechanisms linking psoriasis to eye conditions.
- Discussion of common ophthalmic conditions such as keratoconjunctivitis sicca, blepharitis, conjunctivitis, and uveitis.
Main Results:
- Psoriasis can lead to various eye lesions, including eyelid and conjunctival issues, primarily driven by systemic inflammation.
- Psoriatic treatments themselves may contribute to ocular side effects.
- Uveitis is a serious complication with controversial treatment strategies.
Conclusions:
- Regular ophthalmological screening is essential for patients with psoriasis, irrespective of treatment status.
- Early detection and management of ocular complications are vital to prevent severe outcomes like vision loss.
- Further research is needed to clarify the optimal treatment for psoriatic uveitis.
