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Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal

Xue-Lian Qi1, Ruifeng Liu2, Balbir Singh3

  • 1Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

Cell Reports
|August 4, 2021
PubMed
Summary

Stimulating the nucleus basalis (NB) enhances cognitive function by increasing prefrontal activity during working memory tasks. This neuromodulation improves performance, though it can be hindered by distractors, revealing a stability-accuracy trade-off.

Keywords:
acetylcholinebasal forebraincognitionmonkeyneurophysiology

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