Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In-silico identification of bacterial key-genes directly or indirectly associated with the development and progression of colorectal cancer for exploring anti-bacterial agents.

PloS one·2026
Same author

Cleaning Methods and Microbial Safety of Child Feeding Equipment: A Systematic Review.

Maternal & child nutrition·2026
Same author

Hierarchical stabilization of bioactive hydrogels by multi-arm peptide-polymer supramolecular staples.

Journal of materials chemistry. B·2026
Same author

Mislabel Identification Using Transfer Learning-Based Ensemble Method.

IEEE access : practical innovations, open solutions·2026
Same author

Early feasibility of telemedicine-based mental health wellbeing centers: an implementation study in district and sub-district health facilities in Bangladesh.

BMC health services research·2026
Same author

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif.

Frontiers in molecular neuroscience·2026
Same journal

An intrinsically stretchable nanowire-based sensing patch for wearable analysis of sweat chloride ion composition.

Chemical communications (Cambridge, England)·2026
Same journal

A sterically rigid-flexible balanced NHC-Pd precatalyst for room-temperature solvent-free C-N coupling of benzocyclic amines.

Chemical communications (Cambridge, England)·2026
Same journal

Portable fluorescent conjugated microporous polymer sensor coupled with a smartphone for on-site Fe<sup>3+</sup> detection in water.

Chemical communications (Cambridge, England)·2026
Same journal

Accelerated discovery of NO<sub>3</sub>RR single-atom catalysts <i>via</i> high-throughput DFT and machine learning.

Chemical communications (Cambridge, England)·2026
Same journal

Wafer-scale robust graphene electronics under industrial processing conditions.

Chemical communications (Cambridge, England)·2026
Same journal

Subnanoscale IrW oxide anodes: breaking immiscibility for high activity and durability in water electrolysis.

Chemical communications (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Oct 25, 2025

Force-Clamp Rheometry for Characterizing Protein-based Hydrogels
09:55

Force-Clamp Rheometry for Characterizing Protein-based Hydrogels

Published on: August 21, 2018

7.1K

Force-mediated molecule release from double network hydrogels.

Pavithra Bhakthi Jayathilaka1, Thomas Gregory Molley, Yuwan Huang

  • 1School of Chemistry, University of New South Wales (UNSW Sydney), Sydney, NSW 2052, Australia. k.kilian@unsw.edu.au.

Chemical Communications (Cambridge, England)
|August 5, 2021
PubMed
Summary
This summary is machine-generated.

New hydrogels release molecules when stretched, using a force-triggered chemical reaction. This breakthrough in mechanosensitive polymers offers dynamic control for soft biological materials.

More Related Videos

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

29.3K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.1K

Related Experiment Videos

Last Updated: Oct 25, 2025

Force-Clamp Rheometry for Characterizing Protein-based Hydrogels
09:55

Force-Clamp Rheometry for Characterizing Protein-based Hydrogels

Published on: August 21, 2018

7.1K
Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

29.3K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.1K

Area of Science:

  • Polymer Science
  • Materials Science
  • Chemical Engineering

Background:

  • Mechanosensitive polymers exhibit dynamic force responsivity.
  • Current systems often require high forces for activation.
  • Developing materials with controlled molecular release under force is crucial.

Purpose of the Study:

  • To create novel oxanorbornadiene cross-linked double network hydrogels.
  • To investigate force-mediated molecular release via a retro Diels-Alder reaction.
  • To demonstrate activation at physiologically relevant forces.

Main Methods:

  • Synthesized double network hydrogels using polyacrylamide and alginate.
  • Incorporated oxanorbornadiene cross-linkers sensitive to mechanical force.
  • Utilized a retro Diels-Alder reaction for molecule release upon force application.

Main Results:

  • Achieved significantly higher activation at lower forces compared to pure polymer systems.
  • Demonstrated successful molecular release triggered by mechanical force.
  • The double network structure enhanced force sensitivity and activation efficiency.

Conclusions:

  • Oxanorbornadiene cross-linked hydrogels offer a novel platform for mechanosensitive materials.
  • Physiologically relevant force activation opens possibilities for bio-integrated applications.
  • These materials enable dynamic mechanochemical behavior in soft biological systems.